Targeting tumours with genetically enhanced T lymphocytes

被引：412
|
作者：
Sadelain, M
Rivière, I
Brentjens, R
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10021 USA
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 01期
关键词：
D O I：
10.1038/nrc971
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.
引用
收藏
页码：35 / 45
页数：11
相关论文
共 50 条
  • [1] Targeting tumours with genetically enhanced T lymphocytes
    Michel Sadelain
    Isabelle Rivière
    Renier Brentjens
    Nature Reviews Cancer, 2003, 3 : 35 - 45
  • [2] TARGETING TUMORS WITH GENETICALLY ENHANCED T LYMPHOCYTES
    Sadelain, Michel
    JOURNAL OF GENE MEDICINE, 2009, 11 (12): : 1139 - 1139
  • [3] Targeting tumors with genetically enhanced T lymphocytes.
    Sadelain, M
    BLOOD CELLS MOLECULES AND DISEASES, 2004, 33 (03) : 189 - 190
  • [4] Genetically targeted lymphocytes eradicate B-cell tumours
    Ahmad, K
    LANCET ONCOLOGY, 2003, 4 (04): : 200 - 200
  • [5] Targeting CD19 with genetically modified EBV-speciflc human T lymphocytes
    Roessig, C
    Scherer, SP
    Baer, A
    Vormoor, J
    Rooney, CM
    Brenner, MK
    Juergens, H
    ANNALS OF HEMATOLOGY, 2002, 81 : S42 - S43
  • [6] Targeting of peripheral blood T lymphocytes
    Bolhuis, RLH
    Hoogenboom, HR
    Gratama, JW
    SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1996, 18 (02): : 211 - 226
  • [7] T lymphocytes targeting native receptors
    Rooney, Cliona M.
    Leen, Ann M.
    Vera, Juan F.
    Heslop, Helen E.
    IMMUNOLOGICAL REVIEWS, 2014, 257 (01) : 39 - 55
  • [8] Modulation of alloreactivity using genetically modified T lymphocytes
    Tiberghien, P
    TRANSFUSION CLINIQUE ET BIOLOGIQUE, 1997, 4 (03) : 275 - 280
  • [9] Antigens recognized by T-lymphocytes on human tumours
    Coulie, PG
    VandenEynde, BJ
    vanderBruggen, P
    VanPel, A
    Boon, T
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1997, 25 (02) : 544 - 548
  • [10] Targeting cancer antigens using the adoptive transfer of genetically engineered lymphocytes
    Rosenberg, S.
    ANNALS OF ONCOLOGY, 2008, 19 : 21 - 21
12345