siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

被引：35
|
作者：
Naito, Yuki
Ui-Tei, Kumiko
Nishikawa, Toru
Takebe, Yutaka
Saigo, Kaoru
机构：
[1] Univ Tokyo, Grad Sch Sci, Dept Biophys & Biochem, Bunkyo Ku, Tokyo 1130033, Japan
[2] Univ Tokyo, Sch Sci, Undergrad Program Bioinformat & Syst Biol, Bunkyo Ku, Tokyo 1130033, Japan
[3] Univ Tokyo, Grad Sch Informat Sci & Technol, Dept Comp Sci, Bunkyo Ku, Tokyo 1130033, Japan
[4] AIDS Res Ctr, Lab Mol Virol & Epidemiol, Natl Inst Infect Dis, Shinjuku Ku, Tokyo 1628640, Japan
来源：
NUCLEIC ACIDS RESEARCH | 2006年 / 34卷
关键词：
D O I：
10.1093/nar/gkl214
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
siVirus ( http://siVirus.RNAi.jp/)is a web- based online software system that provides efficient short interfering RNA ( siRNA) design for antiviral RNA interference ( RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/ functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus ( HIV), hepatitis C virus ( HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.
引用
收藏
页码：W448 / W450
页数：3
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