Genetic Variants, Circulating Level of MCP1 with Risk of Chronic Obstructive Pulmonary Disease: A Case-Control Study

被引:6
|
作者
Lin, Chunyi [1 ]
Wang, Zhimin [2 ]
Shen, Lu [1 ]
Yi, Gao [1 ]
Li, Meichan [1 ]
Li, Defu [1 ]
机构
[1] Guangzhou Med Univ, Resp Med, Affiliated Hosp 5, Guangzhou 510700, Peoples R China
[2] Guangzhou Med Univ, Intens Care Unit ICU, Affiliated Hosp 5, Guangzhou 510700, Peoples R China
来源
PHARMACOGENOMICS & PERSONALIZED MEDICINE | 2021年 / 14卷
关键词
COPD; variation; genetic; MCP1; case-control study; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ALVEOLAR MACROPHAGES; INFLAMMATION; POLYMORPHISM; ASSOCIATION;
D O I
10.2147/PGPM.S303799
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Chronic obstructive pulmonary disease (COPD) ranks one of the major causes of mortality worldwide. Inflammation is greatly involved in the pathogenesis of COPD. Monocyte chemoattractant protein-1 (MCP1) has been implicated to play an important role in the inflammatory response of various pathological processes. Methods: In this study, we conducted a hospital-based case-control study in a Chinese population, aiming to evaluate the potential associations of genetic polymorphisms of the MCP1 gene (rs1024611, rs2857656, and rs4586) and circulating level of MCP1 with COPD risk. Results: We found that rs1024611 (OR=1.37; 95% CI=1.11-1.69; P-value=0.004) and rs4586 (OR=1.33; 95% CI=1.09-1.63; P-value=0.006) were significantly associated with increased COPD risk. In the dominant model, both rs1024611 (OR=1.46; 95% CI=1.11-1.92; P-value=0.006) and rs4586 (OR=1.56; 95% CI=1.18-2.07; P-value=0.002) were significantly associated with increased COPD risk. Genotypes of rs1024611 and rs4586 with minor alleles had a significantly higher circulating level of MCP1 (P<0.001). Meanwhile, a circulating level of MCP1 was significantly associated with increased COPD risk (OR for per quartile increment=1.35, 95% CI=1.21-1.52, P<0.001). Conclusion: Our study indicated that genetic polymorphisms of the MCP1 gene and circulating level of MCP1 contributed to the COPD risk in the Chinese population. MCP1 contributed importantly to the pathophysiological process and occurrence of COPD.
引用
收藏
页码:561 / 567
页数:7
相关论文
共 50 条
  • [41] The association of genetic polymorphisms of hypoxia inducible factor-1 alpha and vascular endothelial growth factor with increased risk of chronic obstructive pulmonary disease: A case-control study
    Yu, Zhen-Gang
    Wang, Bing-Zhe
    Cheng, Zhao-Zhong
    KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2017, 33 (09): : 433 - 441
  • [42] Examining Pleiotropic Associations of Genetic Risk Variants for Chronic Obstructive Pulmonary Disease with Lung Cancer Risk
    Sakoda, Lori
    Thai, Khanh
    Roubinian, Nareg
    Iribarren, Carlos
    Schaefer, Catherine
    Risch, Neil
    Habel, Laurel
    Quesenberry, Charles, Jr.
    Jorgenson, Eric
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) : S257 - S258
  • [43] Venous thromboembolic (VTE) disease in people with chronic obstructive pulmonary disease (COPD): A matched case-control study
    Morgan, Ann
    Herriett, Emily
    Smeeth, Liam
    DeStavola, Bianca
    Quint, Jennifer
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [44] Life-Long Physical Activity Involvement Reduces the Risk of Chronic Obstructive Pulmonary Disease: A Case-Control Study in Japan
    Hirayama, Fumi
    Lee, Andy H.
    Hiramatsu, Tetsuo
    JOURNAL OF PHYSICAL ACTIVITY & HEALTH, 2010, 7 (05): : 622 - 626
  • [45] Chronic Obstructive Pulmonary Disease and the Risk of Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma A Primary Care Case-Control Study
    Menon, Shyam
    Nightingale, Peter
    Trudgill, Nigel
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2019, 53 (10) : E451 - E455
  • [46] Genetic Risk Factors in Chronic Obstructive Pulmonary Disease
    Mutlu, Levent Cem
    Guelbas, Gazi
    Guenen, Hakan
    EURASIAN JOURNAL OF PULMONOLOGY, 2012, 14 (01) : 1 - 5
  • [47] Genetic Variants of Matrix Metalloproteinases 1, 9 and 12 in Chronic Obstructive Pulmonary Disease
    Haq, I.
    Chappell, S.
    Johnson, S. R.
    Daly, L.
    Morgan, K.
    Baranes, T. G.
    Roca, J.
    Rabinovich, R.
    Lotya, J.
    Millar, A. B.
    Donnelly, S. C.
    Keatings, V.
    MacNee, W.
    Stolk, J.
    Hiemstra, P. S.
    Miniati, M.
    Monti, S.
    O'Connor, C. M.
    Kalsheker, N.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179
  • [48] Genetic risk factors for chronic obstructive pulmonary disease
    Sandford, AJ
    Joos, L
    Paré, PD
    CURRENT OPINION IN PULMONARY MEDICINE, 2002, 8 (02) : 87 - 94
  • [49] Genetic risk factors for chronic obstructive pulmonary disease
    Sandford, AJ
    Weir, TD
    Pare, PD
    EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (06) : 1380 - 1391
  • [50] Genetic risk factors for chronic obstructive pulmonary disease
    Sandford, AJ
    Paré, PD
    CLINICS IN CHEST MEDICINE, 2000, 21 (04) : 633 - +