Identification of miRNA signature for predicting the prognostic biomarker of squamous cell lung carcinoma

被引：6
|
作者：
Liu, Huanqing [1 ,2 ]
Li, Tingting [3 ]
Dong, Chunsheng [4 ]
Lyu, Jun [1 ,2 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Clin Res Ctr, Xian, Shaanxi, Peoples R China
[2] Jinan Univ, Affiliated Hosp 1, Dept Clin Res, Guangzhou, Guangdong, Peoples R China
[3] Xian Chest Hosp, Dept Pharm, Xian, Shaanxi, Peoples R China
[4] Shaanxi Normal Univ, Sch Comp Sci, Xian, Shaanxi, Peoples R China
来源：
PLOS ONE | 2022年 / 17卷 / 03期
关键词：
MICRORNA EXPRESSION; POOR-PROGNOSIS; GASTRIC-CANCER; PROLIFERATION; METASTASIS; LNCRNA; NETWORK;
D O I：
10.1371/journal.pone.0264645
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
As explorations deepen, the role of microRNAs (miRNAs) in lung squamous cell carcinoma (LUSC), from its emergence to metastasis and prognosis, has elicited extensive concern. LUSC-related miRNA and mRNA samples were acquired from The Cancer Genome Atlas (TCGA) database. The data were initially screened and pretreated, and the R platform and series analytical tools were used to identify the specific and sensitive biomarkers. Seven miRNAs and 15 hub genes were found to be closely related to the overall survival of patients with LUSC. Determination of the expression of these miRNAs can help improve the overall survival of LUSC patients. The 15 hub genes correlated with overall survival (OS). The new miRNA markers were identified to predict the prognosis of LUSC. The findings of this study offer novel views on the evolution of precise cancer treatment approaches with high reliability.
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收藏
页数：20
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