Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats

被引：1
|
作者：
Borovskaya, T. G. [1 ]
Poluektova, M. E. [1 ]
Vychuzhanina, A. V. [1 ]
Mashanova, V. A. [1 ]
Shchemerova, Yu. A. [1 ]
机构：
[1] Russian Acad Sci, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk Natl Res Med Ctr, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 163卷 / 02期
关键词：
antiviral drug Kagocel; reproductive function in male rats; puberty;
D O I：
10.1007/s10517-017-3769-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied possible toxic effects of antiviral drug Kagocel on reproductive function in pubertal male rats. The drug was administered in therapeutic and 10-fold higher doses throughout the spermatogenesis cycle (48 days). Kagocel did not reduce mating and fertilizing capacities, did not suppress spermatogenesis, and had no toxic effects on the offspring. The results characterize Kagocel as a drug with a broad reproductive safety profile and demonstrate that the age limits for using Kagocel in pediatric practice can be extended.
引用
收藏
页码：214 / 217
页数：4
相关论文
共 50 条
  • [21] Effect of the histamine receptor antagonist antazoline on reproductive function in male rats
    Ratnasooriya, WD
    Goonasinghe, NN
    Wadsworth, RM
    MEDICAL SCIENCE RESEARCH, 1996, 24 (01): : 63 - 66
  • [22] Prolonged deleterious effects of neonatal handling on reproductive parameters of pubertal male rats
    Mazaro, R
    Lamano-Carvalho, TL
    REPRODUCTION FERTILITY AND DEVELOPMENT, 2006, 18 (04) : 497 - 500
  • [23] Prepubertal exposure to arsenic alters male reproductive parameters in pubertal and adult rats
    Couto-Santos, Felipe
    Ferreira Souza, Ana Claudia
    Sena Bastos, Daniel Silva
    Guimaraes Ervilha, Luiz Otavio
    Ribeiro Dias, Fernanda Carolina
    Araujo, Larissa de Sales
    Facioni Guimaraes, Simone Eliza
    de Oliveira, Leandro Licursi
    Machado-Neves, Mariana
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 409
  • [24] Effects of combining estradiol with stanozolol on reproductive behaviors in pubertal male rats.
    Davis, AL
    McGinnis, MY
    HORMONES AND BEHAVIOR, 2005, 48 (01) : 96 - 96
  • [25] Reproductive function in male rats with chronic nephrosis
    Ortiz, G
    Vilchis, F
    Cárdenas, M
    Cruz, C
    Pedraza-Chaverrí, J
    Menjívar, M
    JOURNAL OF REPRODUCTION AND FERTILITY, 1999, 117 (02): : 223 - 228
  • [26] EXPERIMENTAL UREMIA IN MALE-RATS - EFFECT ON THE REPRODUCTIVE-TRACT AND FERTILITY
    YOGEV, L
    SERBAN, I
    BENJAMIN, G
    YAVETS, H
    HOMONNAI, Z
    CABILI, S
    IAINA, A
    PAZ, G
    RENAL FAILURE, 1993, 15 (02) : 131 - 134
  • [27] PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES OF THE EFFECT OF KETOCONAZOLE ON REPRODUCTIVE FUNCTION IN MALE-RATS
    WANG, JM
    WU, XL
    YOU, W
    LING, LX
    WU, J
    ZHANG, GY
    INTERNATIONAL JOURNAL OF ANDROLOGY, 1992, 15 (05): : 376 - 384
  • [28] THE EFFECT OF AGE ON MALE REPRODUCTIVE FUNCTION
    MURRAY, MJ
    MEACHAM, RB
    WORLD JOURNAL OF UROLOGY, 1993, 11 (02) : 137 - 140
  • [29] Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats
    Herath, CB
    Jin, WZ
    Watanabe, G
    Arai, K
    Suzuki, AK
    Taya, K
    ENDOCRINE, 2004, 25 (02) : 163 - 172
  • [30] Reproductive disorders in pubertal and adult phase of the male rats exposed to vinclozolin during puberty
    Yu, WJ
    Lee, BJ
    Nam, SY
    Ahn, B
    Hong, JT
    Do, JC
    Kim, YC
    Lee, YS
    Yun, YW
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 2004, 66 (07): : 847 - 853
12345