Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats

被引：1
|
作者：
Borovskaya, T. G. [1 ]
Poluektova, M. E. [1 ]
Vychuzhanina, A. V. [1 ]
Mashanova, V. A. [1 ]
Shchemerova, Yu. A. [1 ]
机构：
[1] Russian Acad Sci, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk Natl Res Med Ctr, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 163卷 / 02期
关键词：
antiviral drug Kagocel; reproductive function in male rats; puberty;
D O I：
10.1007/s10517-017-3769-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied possible toxic effects of antiviral drug Kagocel on reproductive function in pubertal male rats. The drug was administered in therapeutic and 10-fold higher doses throughout the spermatogenesis cycle (48 days). Kagocel did not reduce mating and fertilizing capacities, did not suppress spermatogenesis, and had no toxic effects on the offspring. The results characterize Kagocel as a drug with a broad reproductive safety profile and demonstrate that the age limits for using Kagocel in pediatric practice can be extended.
引用
收藏
页码：214 / 217
页数：4
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