Cytotoxic activity of iron(III), cobalt(III), nickel(II), zinc(II), and cadmium(II) complexes of 2-acetylpyrazine thiosemicarbazone: crystal structure of the cobalt(III) complex

被引：17

作者：

Zhang, Dong ^{[1
]}

Li, Qian ^{[1
]}

Li, Ming-Xue ^{[1
]}

Chen, Dan-Yun ^{[1
]}

Niu, Jing-Yang ^{[1
]}

机构：

[1] Henan Univ, Inst Mol & Crystal Engn, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2010年 / 63卷 / 06期

基金：

中国博士后科学基金;

关键词：

2-Acetylpyrazine; Thiosemicarbazone; Metal complexes; Crystal structure; Cytotoxic activity; TRANSITION-METAL-COMPLEXES; 2-BENZOYLPYRIDINE-DERIVED THIOSEMICARBAZONES; N(4)-SUBSTITUTED THIOSEMICARBAZONES; SPECTRAL CHARACTERIZATION; PALLADIUM(II) COMPLEXES; COPPER(II) COMPLEXES; ANTITUMOR; SEMICARBAZONES; PLATINUM(II); AGENTS;

D O I：

10.1080/00958971003706706

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Transition metal complexes [Fe(HL)(2)]Cl-3 center dot 1.5H(2)O (1), [Co(L)(2)] center dot ClO4 center dot H2O (2), Ni(HL)(2) (ClO4)(2) center dot 2H(2)O (3), Zn(HL) L center dot BF4 center dot 2H(2)O (4), and Cd(HL)(2)(ClO4)(2) center dot 2H(2)O (5), where HL = C7H9N5S, 2-acetylpyrazine thiosemicarbazone, have been synthesized. Complex 2 was characterized by elemental analysis, infrared spectra, mass spectra, and single-crystal X-ray diffraction. Preliminary in vitro screening showed that 1, 4, and 5 exhibit higher antitumor activity than 2 and 3 against K562 leucocythemia cancer cell line.

引用

页码：1063 / 1070

页数：8

共 50 条

[21] Synthesis, characterization and biological activity of the complexes of manganese(III), cobalt(III), nickel(II), copper(II) and zinc(II) with salicylaldehyde thiobenzhydrazone
Singh, NK
Singh, DK
Singh, J
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 2001, 40 (10): : 1064 - 1069
[22] Iron(III), cobalt(II,III), copper(II) and zinc(II) complexes of 2-pyridineformamide 3-piperidylthiosemicarbazone
Ketcham, KA
Swearingen, JK
Castiñeiras, A
Garcia, I
Bermejo, E
West, DX
POLYHEDRON, 2001, 20 (28) : 3265 - 3273
[23] Synthesis, characterization, and biological activity of cadmium (II) and antimony (III) complexes based on 2-acetylpyrazine thiosemicarbazones
Wang, Jin
Zhang, Zhi-Meng
Li, Ming-Xue
INORGANICA CHIMICA ACTA, 2022, 530
[24] COBALT(III) AND NICKEL(II) COMPLEXES OF ISONITROSOPROPIOPHENONE
DESHMUKH, RG
THAKKAR, NV
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1985, 24 (12): : 1066 - 1068
[25] STUDIES ON BIS(VANILLIN)BENZIDINE COMPLEXES OF TITANIUM(III), VANADIUM(III), IRON(III), MANGANESE(II), COBALT(II) AND NICKEL(II)
ARVIND
SAYEED, M
IFTIKHAR, K
AHMAD, N
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1995, 34 (01): : 79 - 82
[26] SYNTHESIS AND BIOCIDAL ACTIVITY STUDIES ON SOLID COMPLEXES OF IRON(II,III), COBALT(II,III) AND NICKEL(II) WITH VIOLURIC ACID AND DINITROSORESORCINOL
AWADALLAH, RM
MOHAMED, AE
RAMADAN, AM
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1988, 65 (08) : 532 - 534
[27] Synthesis, characterization, and biological activities of copper(II), zinc(II), iron(III), cobalt(III), and nickel(II) complexes of D-glucosamine
Shen, HY
Liang, SY
Luo, ZF
Zhang, XC
Zhu, XD
SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 2001, 31 (01): : 167 - 177
[28] COPPER(II), NICKEL(II) AND COBALT(III) COMPLEXES OF THIOQUINAZOLONES
DAVE, LD
MATHEW, C
OOMMEN, V
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1983, 22 (05): : 420 - 421
[29] STUDIES ON MANGANESE(II), IRON(II), COBALT(II AND III), NICKEL(II), COPPER(II) AND ZINC(II) COMPLEXES OF ETHOXYTHIOCARBOXYL HYDRAZIDE
SINGH, NK
SRIVASTVA, SC
AGGARWAL, RC
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1983, 22 (08): : 704 - 707
[30] SYNTHESIS AND STRUCTURAL STUDIES OF OXOVANADIUM(IV), CHROMIUM(III), MANGANESE(II), COBALT(II) + COBALT(III), NICKEL(II), COPPER(II) AND ZINC(II) COMPLEXES OF 2-FURANTHIOCARBOXYHYDRAZIDE
SINGH, NK
AGRAWAL, S
AGGARWAL, RC
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1982, 21 (10): : 973 - 976

← 1 2 3 4 5 →