With or without reirradiation in advanced local recurrent nasopharyngeal carcinoma: a case-control study

被引:15
|
作者
Liu, Li-Ting [1 ,2 ,3 ]
Chen, Qiu-Yan [1 ,2 ,3 ]
Tang, Lin-Quan [1 ,2 ,3 ]
Zhang, Lu [1 ,2 ,3 ]
Guo, Shan-Shan [1 ,2 ,3 ]
Guo, Ling [1 ,2 ,3 ]
Mo, Hao-Yuan [1 ,2 ,3 ]
Zhao, Chong [1 ,2 ,3 ]
Guo, Xiang [1 ,2 ,3 ]
Chen, Ming-Yuan [1 ,2 ,3 ]
Qian, Chao-Nan [1 ,2 ,3 ]
Zeng, Mu-Sheng [1 ,2 ]
Hong, Ming-Huang [1 ,2 ,4 ]
Shao, Jian-Yong [1 ,2 ,5 ]
Sun, Ying [1 ,2 ,6 ]
Ma, Jun [1 ,2 ,6 ]
Mai, Hai-Qiang [1 ,2 ,3 ]
机构
[1] Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Canc Ctr, Dept Nasopharyngeal Carcinoma, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Canc Ctr, Good Clin Practice Ctr, Guangzhou 510060, Guangdong, Peoples R China
[5] Sun Yat Sen Univ, Canc Ctr, Dept Mol Diagnost, Guangzhou 510060, Guangdong, Peoples R China
[6] Sun Yat Sen Univ, Canc Ctr, Dept Radiat Oncol, Guangzhou 510060, Guangdong, Peoples R China
来源
BMC CANCER | 2016年 / 16卷
基金
中国国家自然科学基金;
关键词
Recurrent nasopharyngeal carcinoma; Reirradiation; Chemotherapy;
D O I
10.1186/s12885-016-2803-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The study aimed to evaluate the long-term outcome in patients with advanced local recurrent nasopharyngeal carcinoma (NPC) treated with or without reirradiation. Methods: A total of 44 patients treated without reirradiation (non-RT + chemotherapy) were matched with 44 patients treated with reirradiation (re-RT+/-chemtherapy) by age, sex, Karnosky performance score (KPS), rT stage, rN stage, and time interval between initial radiation and recurrence (TI). Overall survival (OS) rate and time to progression (TTP) rate were assessed using Kaplan-Meier method, log-rank test, and Cox regression analysis. Results: From March 2008 to December 2013, a total of 88 well-balanced rT3-4 N0-1 NPC patients were retrospectively analyzed. After a median follow-up of 27 months (range: 6-85), the 5-year OS rate and UP rate was 23.4 %, 39.0 % in the non-RT + chemotherapy group and 27.5 %, 49.8 % in the re-RT+/-chemtherapy group, respectively. Multivariate analysis showed that significant toxic effect was the only significant prognosticator correlated with OS (HR: 2.15, 95 % CI = 1.02-453, p = 0.044). No statistically significant survival differences were observed between the two treatment groups in either univariate or multivariate analyses. Conclusion: Compared with reiradiation, treating advanced local recurrent NPC with chemotherapy alone warrants further validation in the view of its similar survival and more acceptable toxicities.
引用
收藏
页数:8
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