Disturbed surround inhibition in focal hand dystonia

被引：170
|
作者：
Sohn, YH
Hallett, M
机构：
[1] NINDS, Human Motor Control Sect, NIH, Bethesda, MD 20892 USA
[2] Yonsei Univ, Dept Neurol, Coll Med, Seoul 120749, South Korea
[3] Yonsei Univ, Brain Res Inst, Korea Project Med Sci 21, Coll Med, Seoul 120749, South Korea
来源：
ANNALS OF NEUROLOGY | 2004年 / 56卷 / 04期
关键词：
D O I：
10.1002/ana.20270
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Disturbances in surround inhibition could account for various movement disorders. Here we test the functional operation of surround inhibition in focal hand dystonia. Transcranial magnetic stimulation was set to be triggered by self-initiated voluntary flexion of the index finger. During this movement, motor-evoked potential amplitudes from the little finger muscle were significantly suppressed in healthy subjects but enhanced in dystonia patients. This result supports the idea that disturbed surround inhibition is a principal pathophysiological. mechanism of dystonia.
引用
收藏
页码：595 / 599
页数：5
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