Control of Intracellular Calcium Signaling as a Neuroprotective Strategy

被引:47
|
作者
Duncan, R. Scott
Goad, Daryl L.
Grillo, Michael A.
Kaja, Simon
Payne, Andrew J.
Koulen, Peter [1 ]
机构
[1] Univ Missouri, Sch Med, Vis Res Ctr, Kansas City, MO 64108 USA
关键词
calcium; Ca2+; intracellular calcium channel; ion channel; extracellular; intracellular; accessory proteins; associated proteins; G-protein coupled receptors; imaging; microscopy; signaling; neuroprotection; cytoprotection; neurodegeneration; Alzheimer's disease; Huntington's disease; retina; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; METHYL-D-ASPARTATE; PROTEIN-KINASE-C; ALZHEIMERS-DISEASE NEUROFIBRILLARY; PRESENILIN-MEDIATED ENHANCEMENT; DOMAIN-CONTAINING PROTEIN; FOCAL CEREBRAL-ISCHEMIA; INNER PLEXIFORM LAYER; NMDA-RECEPTOR; CANNABINOID RECEPTOR;
D O I
10.3390/molecules15031168
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Both acute and chronic degenerative diseases of the nervous system reduce the viability and function of neurons through changes in intracellular calcium signaling. In particular, pathological increases in the intracellular calcium concentration promote such pathogenesis. Disease involvement of numerous regulators of intracellular calcium signaling located on the plasma membrane and intracellular organelles has been documented. Diverse groups of chemical compounds targeting ion channels, G-protein coupled receptors, pumps and enzymes have been identified as potential neuroprotectants. The present review summarizes the discovery, mechanisms and biological activity of neuroprotective molecules targeting proteins that control intracellular calcium signaling to preserve or restore structure and function of the nervous system. Disease relevance, clinical applications and new technologies for the identification of such molecules are being discussed.
引用
收藏
页码:1168 / 1195
页数:28
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