Solid and pseudopapillary tumor of the pancreas: immunohistochemical and ultrastructural study of 2 pediatric cases

We report 2 cases of solid and pseudopapillary tumors Of the pancreas occurring in female children. Lesions were made of uniform small cells al ranged in solid areas associated with pseudopapillary and cystic patterns. Immunohistochemistry study was positive for neuron-specific enolase, alpha-1 anti-trypsin and vimentin. Ultrastructural study showed an abundant cytoplasm, rich in mitochondria, containing a lot of granules of variable sizes, often disintegrated, and some lipid droplets. The differential diagnosis of this lesion included endocrine armor, pancreatoblastoma and acinar cell carcinoma. It is a rare tumor of the the pancreas with a favorable prognosis after complete resection.