Synthesis of Optically Active α-Trifluoromethylamines by Rearrangement of β-Amino-α-trifluoromethyl Alcohols

被引：8

作者：

Neouchy, Zeina ^{[1
]}

Pardo, Domingo Gomez ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] PSL Univ, CNRS, ESPCI Paris, Lab Chim Organ,Inst Chem Biol & Innovat CBI, 10 Rue Vauquelin, F-75231 Paris 05, France

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 19期

关键词：

HIGHLY ENANTIOSELECTIVE SYNTHESIS; NUCLEOPHILIC TRIFLUOROMETHYLATION; RING EXPANSION; SUBSTITUTED; 3-FLUOROPIPERIDINES; STEREOSPECIFIC REARRANGEMENT; STEREOSELECTIVE-SYNTHESIS; PROLINOLS; CONTRACTION; ENLARGEMENT; REAGENTS;

D O I：

10.1021/acs.orglett.8b02353

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of various optically active alpha-trifluoromethylamines has been realized from beta-amino-alpha-trifluoromethyl alcohols via an aziridinium ion intermediate under kinetic conditions.

引用

页码：6017 / 6021

页数：5

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