Synthesis of Optically Active α-Trifluoromethylamines by Rearrangement of β-Amino-α-trifluoromethyl Alcohols

被引：8
|
作者：
Neouchy, Zeina [1 ]
Pardo, Domingo Gomez [1 ]
Cossy, Janine [1 ]
机构：
[1] PSL Univ, CNRS, ESPCI Paris, Lab Chim Organ,Inst Chem Biol & Innovat CBI, 10 Rue Vauquelin, F-75231 Paris 05, France
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 19期
关键词：
HIGHLY ENANTIOSELECTIVE SYNTHESIS; NUCLEOPHILIC TRIFLUOROMETHYLATION; RING EXPANSION; SUBSTITUTED; 3-FLUOROPIPERIDINES; STEREOSPECIFIC REARRANGEMENT; STEREOSELECTIVE-SYNTHESIS; PROLINOLS; CONTRACTION; ENLARGEMENT; REAGENTS;
D O I：
10.1021/acs.orglett.8b02353
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of various optically active alpha-trifluoromethylamines has been realized from beta-amino-alpha-trifluoromethyl alcohols via an aziridinium ion intermediate under kinetic conditions.
引用
收藏
页码：6017 / 6021
页数：5
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