Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases

被引:10
|
作者
Miyazaki, Tatsuya [1 ]
Sohda, Makoto [1 ]
Sakai, Makoto [1 ]
Kumakura, Yuji [1 ]
Yoshida, Tomonori [1 ]
Kuriyama, Kengo [1 ]
Yokobori, Takehiko [2 ]
Miyazaki, Masaya [3 ]
Hirato, Junko [4 ]
Okumura, Toshiyuki [5 ]
Ishikawa, Hitoshi [5 ]
Sakurai, Hideyuki [5 ]
Kuwano, Hiroyuki [1 ]
机构
[1] Gunma Univ, Grad Sch, Dept Gen Surg Sci, Maebashi, Gunma, Japan
[2] Gunma Univ, Grad Sch, Dept Mol Pharmacol & Oncol, Maebashi, Gunma, Japan
[3] Gunma Univ, Grad Sch, Dept Diagnost & Intervent Radiol, Maebashi, Gunma, Japan
[4] Gunma Univ, Grad Sch, Dept Pathol, Maebashi, Gunma, Japan
[5] Univ Tsukuba, Fac Med, Dept Radiat Oncol, Tsukuba, Ibaraki, Japan
基金
日本学术振兴会;
关键词
alpha-fetoprotein; Barrett's cancer; proton beam therapy; HEPATOID ADENOCARCINOMA; CONCURRENT CHEMOTHERAPY; TUBULAR ADENOCARCINOMA; BARRETTS-ESOPHAGUS; CHEMORADIOTHERAPY; CRYOABLATION; CARCINOMA; ALCOHOL; TRIAL;
D O I
10.2169/internalmedicine.0270-17
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 50-year-old man who presented with a fever and epigastralgia was diagnosed to have esophageal carcinoma which was identified as poorly differentiated adenocarcinoma producing alpha-fetoprotein (AFP) with Barrett's esophagus. Computed tomography revealed multiple liver metastases and lymph node metastases surrounding the stomach. We first performed chemotherapy for the systemic lesions and proton beam therapy for the local control of lesions without complete remission and we were able to successfully control the frequently recurring lesions by proton beam therapy, cryotherapy and chemotherapy. A complete response has been maintained for 16 months and the overall survival time is 4 years and 2 months. Proton beam therapy for primary esophageal cancer and metastatic lesions was thus found to be an effective therapeutic option for such cases.
引用
收藏
页码:2333 / 2339
页数:7
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