The thrill can kill: Murder by methylation

被引：1
|
作者：
Barik, Sailen [1 ]
机构：
[1] Univ S Alabama, Dept Biochem & Mol Biol, Coll Med, Mobile, AL 36688 USA
来源：
MOLECULAR PHARMACOLOGY | 2007年 / 71卷 / 05期
关键词：
D O I：
10.1124/mol.107.035196
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Why babies of crack-cocaine mothers develop heart problems has always been a mystery. In this issue of Molecular Pharmacology, Zhang et al. ( p. 1319) show that a specific methylation occurs at the protein kinase C epsilon (PKC epsilon) promoter of the babies born of mother rats exposed to cocaine. This reduces the expression of PKC epsilon, a naturally cardioprotective enzyme, which provides a plausible molecular mechanism for cardiac failure.
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页码：1203 / 1205
页数：3
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