The thrill can kill: Murder by methylation

被引：1

作者：

Barik, Sailen ^{[1
]}

机构：

[1] Univ S Alabama, Dept Biochem & Mol Biol, Coll Med, Mobile, AL 36688 USA

来源：

MOLECULAR PHARMACOLOGY | 2007年 / 71卷 / 05期

关键词：

D O I：

10.1124/mol.107.035196

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Why babies of crack-cocaine mothers develop heart problems has always been a mystery. In this issue of Molecular Pharmacology, Zhang et al. ( p. 1319) show that a specific methylation occurs at the protein kinase C epsilon (PKC epsilon) promoter of the babies born of mother rats exposed to cocaine. This reduces the expression of PKC epsilon, a naturally cardioprotective enzyme, which provides a plausible molecular mechanism for cardiac failure.

引用

页码：1203 / 1205

页数：3

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