Effect of particle size on interfacial bonding strength of bilayer tablets

被引：5

作者：

Chang, Shao-Yu ^{[1
]}

Sun, Changquan Calvin ^{[1
]}

机构：

[1] Univ Minnesota, Coll Pharm, Dept Pharmaceut, Pharmaceut Mat Sci & Engn Lab, 9-1272B Weaver Densford Hall,308 Harvard St SE, Minneapolis, MN 55455 USA

来源：

POWDER TECHNOLOGY | 2019年 / 356卷

关键词：

Bilayer tablet; Bonding strength; Bonding area; Interfacial bonding strength; Particle size; COMPACTION PROPERTIES; DIRECT COMPRESSION; TENSILE-STRENGTH; TRUE DENSITY; FRAGMENTATION; TABLETABILITY; DEFORMATION; FORMULATION; MECHANISMS; BEHAVIOR;

D O I：

10.1016/j.powtec.2019.07.100

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The effect of particle size on interfacial bonding strength (IBS) of bilayer tablets was studied using microcrystalline cellulose (MCC) and lactose anhydrate. When MCC is in the first layer, IBS is generally lower and more sensitive to particle size and mechanical properties of the second layer material. In contrast, when lactose is in the first layer, the IBS is higher and less influenced by either of these factors. On the other hand, the use of MCC in the second layer leads to higher IBS than lactose. The dependence of IBS on material and particle size can be explained by bonding area (BA) - bonding strength (BS) interplay. IBS generally increases with increasing BA, which is favored by larger particles in the second layer. However, variations in particle size of the first layer powder did not significantly affect IBS. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：97 / 101

页数：5

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