Synthesis, structure and DNA cleavage of mononuclear Fe(III) complexes with 1,2,4-triazole-base ligand

被引：10
|
作者：
Liu, Hui [1 ,2 ]
Kou, Ying-ying [1 ]
Feng, Li [3 ]
Li, Dong-dong [1 ]
Gao, Chun-Yan [1 ]
Tian, Jin-lei [1 ]
Zhang, Jing-yan [2 ]
Yan, Shi-ping [1 ]
机构：
[1] Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
[2] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
[3] Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2010年 / 24卷 / 09期
基金：
中国国家自然科学基金;
关键词：
iron (III) complex; 1,2,4-triazole; crystal structure; DNA binding; DNA cleavage; CRYSTAL-STRUCTURE; COPPER(II) COMPLEXES; DINUCLEAR COPPER(II); METAL-COMPLEXES; BINDING; FLUORESCENCE; DERIVATIVES; ACID;
D O I：
10.1002/aoc.1659
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new mononuclear iron(III) complexes, [Fe(HL)(2)](ClO4) center dot (H2O)(1.75) center dot CH3CN (1) and [Fe(HL)Cl-2] center dot DMF (2) (H2L = 3-(2-phenol)5-(pyridin-2-yl)-1,2,4-triazole) have been synthesized and characterized by X-ray single-crystal structure analysis. The single crystal X-ray crystallographic studies reveal that the central iron atom has a distorted octahedral environment for 1 and a distorted square pyramidal geometry for 2. The DNA cleavage activity of the iron(III) complexes was measured, indicating that the six-coordinated iron(III) (complex 1) was cleavage inactive and only five-coordinated complex 2 effectively promoted the cleavage of plasmid DNA in the presence and/or absence of activating agents (peroxide oxygen) at physiological pH and temperature. The mechanism of plasmid DNA cleavage was also studied by adding standard radical scavengers. Copyright (C) 2010 John Wiley & Sons, Ltd.
引用
收藏
页码：636 / 640
页数：5
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