BMP2 signaling in bone development and repair

被引：289
|
作者：
Rosen, Vicki [1 ]
机构：
[1] Harvard Univ, Sch Dent Med, Dept Dev Biol, Boston, MA 02115 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 5-6期
关键词：
BMP; Endochondral ossification; Fracture healing; Bone regeneration; OSTEOBLAST PROGENITORS; BETA-CATENIN; CELL-DEATH; STEM-CELLS; DIFFERENTIATION; LIMB; CARTILAGE; SKELETOGENESIS; CHONDROGENESIS; OSTEOPOROSIS;
D O I：
10.1016/j.cytogfr.2009.10.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
BMPs are best known for their actions as bone formation signals. Recent studies using transgenic mice in which individual osteogenic BMPs have been removed from the limb skeleton have identified BMP2 as a fundamental component of the inherent regenerative capacity of bone. This review summarizes current findings on the specific requirement for BMP2 in bone formation and repair. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：475 / 480
页数：6
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