TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction

被引：17
|
作者：
Hu, Jiaxing [1 ]
Qin, Hua-Li [1 ]
Xu, Wengang [1 ]
Li, Junli [1 ]
Zhang, Fanglin [1 ]
Zheng, Hua [1 ]
机构：
[1] Wuhan Univ Technol, Dept Pharmaceut Engn, Wuhan 430070, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 99期
基金：
中国国家自然科学基金;
关键词：
FRIEDEL-CRAFTS ALKYLATION; 3-SUBSTITUTED ISOINDOLINONES; EFFICIENT SYNTHESIS; SELECTIVE SYNTHESIS; ALLYLIC ALCOHOLS; SECONDARY-AMINES; CYCLIZATION; DERIVATIVES; INHIBITORS; ISOINDOLIN-1-ONES;
D O I：
10.1039/c4cc06653g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C-H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.
引用
收藏
页码：15780 / 15783
页数：4
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