Resistance of herpes simplex virus type 1 to acyclovir: Thymidine kinase gene mutagenesis study

被引：19

作者：

Frobert, Emilie

Ooka, Tadamasa

Cortay, Jean-Claude

Lina, Bruno

Thouvenot, Danielle

Morfin, Florence

机构：

[1] Hospices Civils Lyon, Lab Virol Est, F-69373 Lyon 08, France

[2] Univ Lyon 1, Fac Med Laennec, CNRS,UMR 5537, Lab Virol & Pathogenese Virale, F-69372 Lyon, France

来源：

ANTIVIRAL RESEARCH | 2007年 / 73卷 / 02期

关键词：

herpes simplex virus; ACV resistance; thymidine kinase; site-directed mutagenesis;

D O I：

10.1016/j.antiviral.2006.08.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

By site-directed mutagenesis, we investigate the role of six mutations of herpes simplex virus type 1 thymidine kinase (TK) gene in the acquisition of resistance to acyclovir (ACV). TK activity was not impaired by substitutions located at codons 17, 161 and 374 and these mutations were thus related to TK gene polymorphism. Mutations His 105Pro, Leu364Pro and Asp 162Ala lead to the loss of TK activity that could result in ACV-resistance. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：147 / 150

页数：4

共 50 条

[41] HERPES-SIMPLEX VIRUS (TYPE-1) THYMIDINE KINASE GENE DOES NOT TRANSFORM CELLS MORPHOLOGICALLY
HAMPAR, B
DERGE, JG
BOYD, AL
TAINSKY, MA
SHOWALTER, SD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (04): : 2616 - 2619
[42] LOCALIZATION OF THE THYMIDINE KINASE GENE OF HERPES-SIMPLEX VIRUS TYPE-2 (333)
VANDENBERG, FM
WALBOOMERS, JMM
INTERVIROLOGY, 1980, 14 (3-4) : 217 - 222
[43] LOCATION AND CLONING OF THE HERPES-SIMPLEX VIRUS TYPE-2 THYMIDINE KINASE GENE
MCDOUGALL, JK
MASSE, TH
GALLOWAY, DA
JOURNAL OF VIROLOGY, 1980, 33 (03) : 1221 - 1224
[44] ACYCLOVIR RESISTANCE IN HERPES-SIMPLEX VIRUS TYPE-1 - BIOCHEMICAL AND FUNCTIONAL-STUDIES ON THE THYMIDINE KINASE OF THE HIGHLY RESISTANT R100-STRAIN
PALU, G
BEVILACQUA, F
BIASOLO, MA
PAROLIN, C
TOGNON, M
ROMANELLI, MG
MELONI, GA
VIRUS RESEARCH, 1989, 13 (04) : 303 - 318
[45] Intracellular localization of herpes simplex virus type 1 thymidine kinase in virus-infected cells
Bae, PK
Nam, JR
Kim, HS
Lee, MJ
Chung, IK
Lee, CK
ANTIVIRAL RESEARCH, 2005, 65 (03) : A76 - A76
[46] HERPES SIMPLEX VIRUS TYPE 2 UL23 THYMIDINE KINASE: MOLECULAR DETECTION OF POLYMORPHISM AND MUTATIONS ASSOCIATED WITH ACYCLOVIR RESISTANCE IN SOUTH AFRICA
Muller, E. E.
Magooa, M. P.
Lewis, D. A.
SEXUALLY TRANSMITTED INFECTIONS, 2013, 89 : A77 - A78
[47] Differential mutation patterns in thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 clones passaged in the presence of acyclovir or penciclovir
Suzutani, T
Ishioka, K
De Clercq, E
Ishibashi, K
Kaneko, H
Kira, T
Hashimoto, K
Ogasawara, M
Ohtani, K
Wakamiya, N
Saijo, M
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (05) : 1707 - 1713
[48] Extended substrate acceptance of herpes simplex virus type 1 thymidine kinase:: a new chance for gene and antiviral therapy
Scapozza, L
Ballmer, P
Johner, R
Perozzo, R
Pilger, B
Pospisil, P
Prota, A
Schelling, P
Spadola, L
Wurth, C
Folkers, G
CHIMIA, 2000, 54 (11) : 663 - 668
[49] In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU
Haubner, R
Avril, N
Hantzopoulos, PA
Gansbacher, B
Schwaiger, M
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 2000, 27 (03) : 283 - 291
[50] Detection of mutations within the thymidine kinase gene of herpes simplex virus type 1 by denaturing gradient gel electrophoresis
Lu, QS
Hwang, YT
Hwang, CBC
JOURNAL OF VIROLOGICAL METHODS, 2002, 99 (1-2) : 1 - 7

← 1 2 3 4 5 →