Mueller-matrix mapping of optically anisotropic fluorophores of biological tissues in the diagnosis of cancer

被引:15
|
作者
Ushenko, Yu. A. [1 ]
Sidor, M. I. [1 ]
Bodnar, G. B. [2 ]
Koval', G. D. [2 ]
机构
[1] Yuriy Fedkovych Chernivtsi Natl Univ, UA-58012 Chernovtsy, Ukraine
[2] Bukovinian State Med Univ, UA-58000 Chernovtsy, Ukraine
关键词
autofluorescence; polarisation; birefringence; optical anisotropy; Mueller matrix; statistical moments; diagnostics; POLARIZATION PROPERTIES; ALIGNMENT MAPS; FLUORESCENCE; BIREFRINGENCE; SPECTROSCOPY; TUMORS; LIGHT;
D O I
10.1070/QE2014v044n08ABEH015295
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
We report the results of studying the polarisation manifestations of laser autofluorescence of optically anisotropic structures in biological tissues. A Mueller-matrix model is proposed to describe their complex anisotropy (linear and circular birefringence, linear and circular dichroism). The relationship is established between the mechanisms of optical anisotropy and polarisation manifestations of laser autofluorescence of histological sections of rectal tissue biopsy in different spectral regions. The ranges of changes in the statistical moments of the 1st-to-4th orders, which describe the distribution of the azimuth-invariant elements of Mueller matrices of rectal tissue autofluorescence, are found. Effectiveness of laser autofluorescence polarimetry is determined and the histological sections of biopsy of benign (polyp) and malignant (adenocarcinoma) tumours of the rectal wall are differentiated for the first time.
引用
收藏
页码:785 / 790
页数:6
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