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Phosphorylation of C(sp3)-H Bonds via 1,4-Palladium Migration
被引:15
|作者:
Ji, Xiao-Ming
[1
]
Chen, Yan-Zhen
[1
]
Fu, Jian-Guo
[1
]
Zhang, Shu-Sheng
[1
]
Feng, Chen-Guo
[1
,2
]
机构:
[1] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Res Ctr Chiral Drugs, Shanghai 201203, Peoples R China
[2] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China
基金:
中国博士后科学基金;
中国国家自然科学基金;
关键词:
C-H ACTIVATION;
ARYL;
1,4-MIGRATION;
BORYLATION;
D O I:
10.1021/acs.orglett.2c01303
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
1,4-Palladium migration has emerged as a reliable method for directed C-H functionalization. In contrast to coupling with carbon nucleophiles, limited examples with heteroatom nucleophiles have been reported. Herein we report a palladium-catalyzed intermolecular C(sp3)-H phosphorylation reaction via 1,4-palladium migration, which is often difficult because of the strong coordination of phosphorus reagents to palladium catalysts. Phosphorylation of C(sp3)-H bonds is accomplished in good reaction yields with excellent regioselectivity. The judicious selection of the phosphine ligand proved to be the key to the success of this cascade process.
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页码:3781 / 3785
页数:5
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