Cytogenetic study of Brazilian patients with myelodysplastic syndrome (MDS)

被引:3
|
作者
Borgonovo, Tamara
Ribeiro, Enilze M. S. F.
Cornelio, Deborah Afonso
Schmid-Braz, Ana Teresa
Jamur, Valderez Ravaglio
Wuicik, Lismeri
Acosta Veiga, Loraine Beatriz
Ehmke, Neria A. Maia
Pasquini, Ricardo
Cavalli, Iglenir Joao
机构
[1] Univ Fed Parana, Dept Genet, Lab Citogenet Humana, BR-81531970 Curitiba, Parana, Brazil
[2] Univ Fed Parana, Hosp Clin, Lab Citogenet & Imunogenet, BR-81531970 Curitiba, Parana, Brazil
[3] Univ Fed Parana, Hosp Clin, Serv Transplante Medula Ossea, BR-81531970 Curitiba, Parana, Brazil
关键词
hematological disorders; myelodysplasias; cancer cytogenetics;
D O I
10.1590/S1415-47572005000500002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bone marrow cytogenetic studies were performed on 93 patients with primary myelodysplastic syndrome (MDS) diagnosed at the Clinical Hospital of the Federal University of Parana, Brazil. Chromosomal alterations were observed in 69% of the patients. Monosomy of chromosome 7, deletions of 7q, 5q, 12p and 20q, rearrangements of 11q23 and trisomies of chromosomes 8 and 21 were the most frequent abnormalities observed. Among adult patients the most frequent aberrations were rearrangements of 11q23 and 12p deletions. In the pediatric group, 5q deletions and monosomy of chromosome 7 were the most common alterations.
引用
收藏
页码:654 / 660
页数:7
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