Chromatographic determination of high-molecular weight impurities in amoxicillin

被引：31
|
作者：
Cai, SY [1 ]
Hu, CQ [1 ]
Xu, MZ [1 ]
机构：
[1] Natl Inst Control & Pharmaceut & Biol Prod, Beijing 100050, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2003年 / 31卷 / 03期
关键词：
amoxicillin high molecular weight impurities; gel filtration chromatography; reversed phase liquid chromatography;
D O I：
10.1016/S0731-7085(02)00711-2
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The separation of high molecular weight impurities in amoxicillin has been examined by three methods of gel filtration chromatography (GFC) and reversed phase liquid chromatography (RPLC). Specificity of GFC was checked by applying the method for the determination of amoxicillin and its related impurities and linking of GFC and RPLC. The result shows that for the determination of polymers the gel filtration chromatography is a rather simple separation mode as compared to RPLC. Regarding the three gel filtration chromatographic methods, the separation on the Superdex peptide column is advantageous over other methods of determining amoxicillin polymers. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：589 / 596
页数：8
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