Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain

被引：55

作者：

Quintana, E. ^{[1
,2
,3
]}

Coll, C. ^{[1
]}

Salavedra-Pont, J. ^{[1
]}

Munoz-San Martin, M. ^{[1
]}

Robles-Cedeno, R. ^{[1
,2
,3
]}

Tomas-Roig, J. ^{[1
]}

Buxo, M. ^{[4
]}

Matute-Blanch, C. ^{[5
]}

Villar, L. M. ^{[2
,6
]}

Montalban, X. ^{[2
,5
]}

Comabella, M. ^{[2
,5
]}

Perkal, H. ^{[1
]}

Gich, J. ^{[1
,3
]}

Ramio-Torrenta, L. ^{[1
,2
,3
]}

机构：

[1] Dr Josep Trueta Univ Hosp, Neuroimmunol & Multiple Sclerosis Unit, Girona Biomed Res Inst, IDIBGI,Neurol Dept, Dr Castany S-N, Salt 17190, Girona, Spain

[2] REEM, Madrid, Spain

[3] Univ Girona, Fac Med, Dept Med Sci, Girona, Spain

[4] IDIBGI, Girona Biomed Res Inst, Girona, Spain

[5] Univ Autonoma Barcelona, Serv Neurol Neuroimmunol, Ctr Esclerosi Multiple Catalunya Cemcat, Inst Recerca Vall Hebron,VHIR,Hosp Univ Vall Hebr, Barcelona, Spain

[6] Hosp Ramon & Cajal, Dept Immunol, IRYCIS, Madrid, Spain

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2018年 / 25卷 / 09期

关键词：

biomarkers; chitinase; 3-like; 1; mild cognitive impairment; multiple sclerosis; neurofilament light chain; MINIMAL ASSESSMENT; BIOMARKERS; TESTS; MS;

D O I：

10.1111/ene.13687

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose: Chitinase 3-like 1 (CHI3L1) and neurofilament light chain (NF-L) are promising biomarkers of disability in multiple sclerosis (MS). However, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid (CSF) levels of CHI3L1 and NF-L with cognitive status in MS. Methods: Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF-L were determined by ELISA. Spearman's partial correlation coefficient was performed. Results: After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A (rs = 0.348; p = 0.016) and between NF-L levels and Word List Generation (rs = -0.324; p = 0.025). Conclusion: High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS.

引用

页码：1189 / 1191

页数：3

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