Effects of metformin on serum levels of sex hormone, leptin and insulin in ovariectomized Sprague-Dawley rats

被引：4
|
作者：
Yan, Li [1 ]
Kang, Bai [1 ]
Li, Guangzhou [2 ]
Yin, Zhaozhen [1 ]
Wang, Yanyan [1 ]
机构：
[1] Weifang Med Coll, Dept Pharmacol, Weifang 261042, Shandong, Peoples R China
[2] Weifang Med Coll, Dept Nucl Med, Affiliated Hosp, Weifang 261042, Shandong, Peoples R China
来源：
PHARMAZIE | 2009年 / 64卷 / 12期
关键词：
WOMEN;
D O I：
10.1691/ph.2009.9646
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The aim of the present experiment was to study the effects of metformin (MF) on serum concentrations of sex hormone,leptin and insulin in ovariectomized (OVX) Sprague-Dawley (SD) rats. The serum estradiol (E-2), progesterone (P), leptin and insulin concentrations were measured with radioimmunoassay (RIA). Compared with SHAM operated rats, the serum concentrations of E-2 and P were significantly lower (P < 0.01), but leptin and insulin were significantly higher in OVX rats (P < 0.01). MF (135 mg kg(-1) d(-1), ig, 30 d) had no evident effects on serum concentrations of E2, P, leptin and insulin in OVX rats. MF (270 mg kg(-1) d(-1), ig, 30 d) markedly increased serum concentrations of E-2 and P (P < 0.05) while decreased serum concentrations of leptin and insulin (P < 0.05 and P < 0.01) in OVX rats. We concluded that long-term treatment of high dose MF cannot only significantly decrease serum concentrations of leptin and insulin, but also increase E-2 and P in OVX SID rats.
引用
收藏
页码：834 / 835
页数：2
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