Validity of childhood disintegrative psychosis - General findings of a long-term follow-up study

Background Empirical evidence for the validity or the diagnostic label 'disintegrative psychosis' is sparse. The issue of whether it is a separate form of infantile autism is unresolved. Method To investigate the validity of disintegrative psychosis as defined in ICD-9, the natural history of 13 cases were compared with 39 matched cases of infantile autism on various outcome variables. Average follow-up time was 22 (11-33) years. Results Statistically significant differences were found between the two groups in terms of number of admissions to nbn-psychiatric departments, occurrence of comorbid epilepsy social style, and score on the Global Assessment of Functioning scale. In most other areas assessed there was a tendency, although statistically insignificant, towards a better outcome in the infantile autism comparison group. Conclusions Our findings provide some support for maintaining a diagnostic category of disintegrative psychosis as distinct from infantile autism.