Allelic association between the D10S1423 marker and Alzheimer's disease in a German population

被引：21
|
作者：
Majores, M [1 ]
Bagli, M [1 ]
Papassotiropoulos, A [1 ]
Schwab, SG [1 ]
Jessen, F [1 ]
Rao, ML [1 ]
Maier, W [1 ]
Heun, R [1 ]
机构：
[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany
来源：
NEUROSCIENCE LETTERS | 2000年 / 289卷 / 03期
关键词：
Alzheimer's disease; chromosome; 10; D10S1423; marker; association;
D O I：
10.1016/S0304-3940(00)01283-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recently a full genome survey detected an allelic association between Alzheimer's disease (AD) and the D10S1423 marker on chromosome 10p12-14 (40 cM from the telomere). in this study we examined the D10S1423 marker in an ethnically homogeneous German population of 80 AD patients and two groups of controls, 168 healthy subjects and 149 depressed patients. The 234-bp allele of the D10S1423 marker showed a significant association with AD (P = 0.033). In conclusion, our results support that the D10S1423 marker is associated with an increased AD risk and provides further evidence for an AD susceptibility locus on chromosome 10. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：224 / 226
页数：3
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