Design and optimization of a near-field scanning optical microscope for imaging biological samples in liquid

被引：31
|
作者：
Gheber, LA [1 ]
Hwang, J [1 ]
Edidin, M [1 ]
机构：
[1] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA
来源：
APPLIED OPTICS | 1998年 / 37卷 / 16期
关键词：
D O I：
10.1364/AO.37.003574
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We describe a near-field scanning optical microscope capable of imaging biological samples in liquid. The microscope uses a straight optical fiber near-field probe and optical sheer-force feedback for tip sample distance regulation. Physical aspects of the design are discussed, and phenomena related to operation in liquid are revealed. Careful calibration of the instrument in air and in liquid is shown, and for the first time to our knowledge, near-field fluorescence images of a biological cell in liquid are presented. (C) 1998 Optical Society of America.
引用
收藏
页码：3574 / 3581
页数：8
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