Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats

被引：29
|
作者：
Titova, Elena
Ostrowski, Robert P.
Sowers, Lawrence C.
Zhang, John H.
Tang, Jiping
机构：
[1] Loma Linda Univ, Med Ctr, Dept Physiol & Pharmacol, Loma Linda, CA 92354 USA
[2] Loma Linda Univ, Dept Biochem & Microbiol, Loma Linda, CA 92350 USA
[3] Loma Linda Univ, Dept Neurosurg, Loma Linda, CA 92350 USA
[4] Loma Linda Univ, Dept Anaesthesiol, Loma Linda, CA 92350 USA
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2007年 / 34卷 / 09期
关键词：
apocynin; collagenase; ethanol; intracerebral haemorrhage; oedema; oxidative stress;
D O I：
10.1111/j.1440-1681.2007.04664.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.
引用
收藏
页码：845 / 850
页数：6
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