Interactive effects of attachment and FKBP5 genotype on school-aged children's emotion regulation and depressive symptoms

被引:19
|
作者
Borelli, Jessica L. [1 ,2 ]
Smiley, Patricia A. [1 ]
Rasmussen, Hannah F. [1 ,3 ]
Gomez, Anthony [1 ]
Seaman, Lauren C. [4 ]
Nurmi, Erika L. [4 ]
机构
[1] Pomona Coll, Dept Psychol, Claremont, CA 91711 USA
[2] Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92717 USA
[3] Univ Southern Calif, Dept Psychol, Los Angeles, CA 90089 USA
[4] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
关键词
Attachment; Genetics; FKBP5; Emotion regulation; Middle childhood; RESPIRATORY SINUS ARRHYTHMIA; INFANT-MOTHER ATTACHMENT; ADVERSE LIFE EVENTS; DIFFERENTIAL SUSCEPTIBILITY; DIATHESIS-STRESS; SEROTONIN TRANSPORTER; FUTURE-DIRECTIONS; BEHAVIOR PROBLEMS; ADULT ATTACHMENT; ADOLESCENTS;
D O I
10.1016/j.bbr.2016.07.035
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Attachment insecurity is influenced by both environmental and genetic factors, but few studies have examined the effects of gene-environment interactions. In the context of environmental stress, a functional variant in the glucocorticoid receptor co-chaperone FKBP5 gene has been repeatedly shown to increase risk for psychiatric illness, including depression. We expand on prior work by exploring cross-sectional attachment by gene effects on both attachment insecurity and downstream physiological and behavioral measures in a diverse community sample of school-aged children (N=99, 49% girls, M-age =10.29 years, 66.6% non-White) and their mothers. Specifically, we examined moderating effects of FKBP5 rs3800373 genotype on the links between parenting insensitivity (overcontrol) and child attachment. Further, we assessed whether FKBP5 moderates the links between maternal and child attachment and children's emotion regulation self-report, respiratory sinus arrhythmia (RSA) in response to a standardized laboratory stressor, and depressive symptoms. Higher levels of overcontrol predicted lower child attachment security only in FKBP5 minor allele carriers. Among children with two minor alleles (CC), attachment security was negatively associated with emotion suppression, rumination, depressive symptoms, and RSA reactivity; similarly, for these children, maternal attachment anxiety was positively associated with depressive symptoms. The findings can be conceptualized in a differential susceptibility framework, where the FKBP5 minor allele confers either risk or resilience, depending on the parenting environment. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:278 / 289
页数:12
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