Association of TNFSF4 (rs3850641) gene polymorphisms and coronary heart disease: an evidence-based meta-analysis

Objective: To clarify the effects of TNFSF4 (rs3850641) polymorphisms on coronary heart disease (CHD) risk. Method: Published literature from Pubmed, Embase, ISI Wed of Knowledge, Cochrane Library, and Chinese databases were retrieved. All studies evaluating the association between TNFSF4 (rs3850641) polymorphisms and CHD risk were included. Summary odds ratios (ORs) and 95% confidence intervals (CI) were calculated employing random effects models irrespective of between-study heterogeneity. Results: A total of 9 eligible studies was included in this meta-analysis. Overall analysis showed that the rs3850641 G allele was not associated with CHD, compared with the A allele, with OR of 1.10 (95% CI, 0.96 - 1.27; p = 0.174). Genotypic analysis showed that there was no significant association between the GG, GA, GG + GA, and CHD, compared with participants with AA, with ORs of 1.23 (95% CI, 0.75 2.03; p = 0.409), 1.04 (95% CI, 0.84 - 1.29; p = 0.705), and 1.07 (95% CI, 0.85 - 1.34; p = 0.589), respectively. On the other hand, in the subgroup analysis by ethnicity, source of controls, genotyping methods, or matching criteria, there was still no statistically significant association between TNFSF4 (rs3850641) polymorphisms and CHD risk. Conclusions: This meta-analysis reveals that TNFSF4 (rs3850641) polymorphisms is not associated with CHD risk.