Inhibition of rabbit gastric epithelial restoration by a water extract of Helicobacter pylori: Evidence using a cultured cell model

被引：0

作者：

Sato, N ^{[1
]}

Watanabe, S ^{[1
]}

Wang, XE ^{[1
]}

Hirose, M ^{[1
]}

Oide, H ^{[1
]}

Kitamura, T ^{[1
]}

Ohkura, R ^{[1
]}

Otaka, K ^{[1
]}

Miwa, H ^{[1
]}

Miyazaki, A ^{[1
]}

Aihara, M ^{[1
]}

Azuma, A ^{[1
]}

Imagawa, K ^{[1
]}

Kikuchi, M ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 113, Japan

来源：

CELL INJURY AND PROTECTION IN THE GASTROINTESTINAL TRACT: FROM BASIC SCIENCES TO CLINICAL PERSPECTIVES 1996 | 1997年

关键词：

gastric epithelial cell; restoration; restitution; Helicobacter pylori; cytotoxin; peptic ulcer;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The detailed mechanism of H. pylori-induced gastric damage is still unknown. in this study, we showed that a water extract of H: pylori retarded the epithelial restoration in a cultured rabbit gastric epithelial cell model with the inhibition of both cell migration and proliferation Although this inhibitory substance has not yet been biochemically characterized, it is different from known H. pylori associate-cytotoxins and ammonia. From these results, we hypothesize that these bacteria directly play a role in disturbance of peptic ulcer healing in vivo.

引用

页码：187 / 195

页数：9

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