Fractional Exhaled Nitric Oxide (FeNO) and Spirometry as Indicators of Inhalation Exposure to Chemical Agents in Pathology Workers

被引：3
|
作者：
Suzuki, Ritsuko Arakawa [1 ]
Irokawa, Toshiya [1 ,2 ]
Ogawa, Hiromasa [1 ,2 ]
Ohkouchi, Shinya [1 ,2 ]
Tabata, Masao [1 ,2 ]
Togashi, Susumu [3 ]
Nakamura, Takeshi [3 ]
Ohisa, Noriko [1 ]
Nikkuni, Etsuhiro [1 ]
Miura, Emiri [1 ]
Yoshida, Kaoru [1 ]
Inomata, Hiroshi [3 ]
Kurosawa, Hajime [1 ,2 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Dept Occupat Hlth, Sendai, Miyagi, Japan
[2] Tohoku Univ, Ctr Environm Conservat & Res Safety, Sendai, Miyagi, Japan
[3] Tohoku Univ, Environm Conservat Ctr, Sendai, Miyagi, Japan
来源：
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2017年 / 59卷 / 05期
基金：
日本学术振兴会;
关键词：
VOLATILE ORGANIC-COMPOUNDS; OCCUPATIONAL ASTHMA; FORMALDEHYDE; AIR;
D O I：
10.1097/JOM.0000000000000976
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective: The objective of this study was to examine whether fractional exhaled nitric oxide (FeNO) and spirometry can be used as indices to evaluate adverse health effects of low-concentrated chemical inhalation exposure, mainly to formaldehyde. Methods: Thirty-three subjects (pathology technicians) and 30 controls (workers without handling any chemicals in the same hospitals) participated in this study. All participants underwent FeNO measurement and spirometry before and after 5 days of work. Results: FeNO significantly increased in the subjects with a history of asthma (P < 0.05), whereas forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) decreased in the subjects (P < 0.05). Furthermore, work duration and pre-work levels of FEV1 in the subjects had a significant association. Conclusion: The results suggest that FeNO, FVC, and FEV1 represent effective health-effect indices of low-concentrated chemical inhalation exposure.
引用
收藏
页码：467 / 473
页数：7
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