Fractional Exhaled Nitric Oxide (FeNO) and Spirometry as Indicators of Inhalation Exposure to Chemical Agents in Pathology Workers

被引：3

作者：

Suzuki, Ritsuko Arakawa ^{[1
]}

Irokawa, Toshiya ^{[1
,2
]}

Ogawa, Hiromasa ^{[1
,2
]}

Ohkouchi, Shinya ^{[1
,2
]}

Tabata, Masao ^{[1
,2
]}

Togashi, Susumu ^{[3
]}

Nakamura, Takeshi ^{[3
]}

Ohisa, Noriko ^{[1
]}

Nikkuni, Etsuhiro ^{[1
]}

Miura, Emiri ^{[1
]}

Yoshida, Kaoru ^{[1
]}

Inomata, Hiroshi ^{[3
]}

Kurosawa, Hajime ^{[1
,2
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Occupat Hlth, Sendai, Miyagi, Japan

[2] Tohoku Univ, Ctr Environm Conservat & Res Safety, Sendai, Miyagi, Japan

[3] Tohoku Univ, Environm Conservat Ctr, Sendai, Miyagi, Japan

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2017年 / 59卷 / 05期

基金：

日本学术振兴会;

关键词：

VOLATILE ORGANIC-COMPOUNDS; OCCUPATIONAL ASTHMA; FORMALDEHYDE; AIR;

D O I：

10.1097/JOM.0000000000000976

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: The objective of this study was to examine whether fractional exhaled nitric oxide (FeNO) and spirometry can be used as indices to evaluate adverse health effects of low-concentrated chemical inhalation exposure, mainly to formaldehyde. Methods: Thirty-three subjects (pathology technicians) and 30 controls (workers without handling any chemicals in the same hospitals) participated in this study. All participants underwent FeNO measurement and spirometry before and after 5 days of work. Results: FeNO significantly increased in the subjects with a history of asthma (P < 0.05), whereas forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) decreased in the subjects (P < 0.05). Furthermore, work duration and pre-work levels of FEV1 in the subjects had a significant association. Conclusion: The results suggest that FeNO, FVC, and FEV1 represent effective health-effect indices of low-concentrated chemical inhalation exposure.

引用

页码：467 / 473

页数：7

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