What MAN1 does to the smads -: TGFβ/BMP signaling and the nuclear envelope

被引：40

作者：

Bengtsson, Luiza ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

来源：

FEBS JOURNAL | 2007年 / 274卷 / 06期

关键词：

BMP; laminopathy; MAN1; nuclear envelope; phosphatase; signal transduction; Smad; TGF beta; TO-AUTOINTEGRATION FACTOR; MEMBRANE PROTEIN MAN1; RNA-RECOGNITION MOTIF; LEM-DOMAIN PROTEIN; A-TYPE LAMINS; DEPENDENT LOCALIZATION; MUSCULAR-DYSTROPHY; INTEGRAL PROTEIN; GENE-EXPRESSION; EMERIN;

D O I：

10.1111/j.1742-4658.2007.05696.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor beta/bone morphogenic protein (TGF beta/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embryos lacking MAN1 develop severe morphological defects. Both in humans and in Xenopus embryos the defects originate from deregulation of TGF beta/BMP signaling. Several independent studies have shown that MAN1 is antagonizing TGF beta/BMP signaling through binding to regulatory Smads. Here, recent progress in understanding MAN1 functions is summarized and a model for MAN1-dependent regulation of TGF beta/BMP signaling is proposed.

引用

页码：1374 / 1382

页数：9

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