ONE POT SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL FUSED THIADIAZOLO-PYRIMIDINE DERIVATIVES

One pot synthesis of 5-amino-7-(substituted-pheny1)-2-(substituted-bezy1)-5-H-[1,3,4]thiadiazolo [3,2-a]pyrimidine-6-carbonitrile (6) was achieved by the reaction of 2-amino-5-(substituted)-benzyl-1,3,4-thiadiazole (3), aromatic aldehyde (4) and malononitrile (5). The contents were refluxed in presence of triethylamine as a catalyst and ethanol as a solvent. The structures of the compounds have been confirmed by IR and NMR. Representative compounds were screened for their anti-microbial activity against gram-negative bacteria, E coli and P.aeruginosaand gram-positive bacteria, S aureus, and C diphtheriaeusing disc diffusion method. Some of these compounds have been found to exhibit excellent antibacterial activity.