Wound healing potential of a polyvinyl alcohol-blended pectin hydrogel containing Hippophae rahmnoides L. extract in a rat model

被引：49
|
作者：
Kim, Jin [1 ]
Lee, Chang-Moon [2 ]
机构：
[1] Chonnam Natl Univ, Dept Adv Chem & Engn, Gwangju 61186, South Korea
[2] Chonnam Natl Univ, Dept Biomed Engn, Yeosu 59662, Jeonnam, South Korea
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2017年 / 99卷
基金：
新加坡国家研究基金会;
关键词：
Hippophae rhamnoides L; Flavonoid; Wound healing; Hydrogel; Inflammation; RHAMNOIDES L; DRUG-DELIVERY; ANTIOXIDANT ACTIVITY; RELEASE; LEAVES;
D O I：
10.1016/j.ijbiomac.2017.03.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, we investigated the effect of a polyvinyl alcohol-blended pectin hydrogel (PVA-PT HG) containing the extracts of Hippophae rhamnoides L. (H. rhamnoides L.) leaves on wound healing in a rat model. The total phenolic content in the extract solution was 40.64 +/- 2.7 GAE mg/g and that of flavonoids was 13.15 +/- 1.8 QE mg/g. Of the total flavonoids in HGs, 61.6 and 50.0% were released at pH 5.5 and 7.4 after 60 min. In rat acute wound models, the wound size was reduced significantly and the recovery rate was significantly higher after treatment with HG containing the extracts, compared with treatment with the control and HG only. The wound healing effects of the HG containing the extracts were confirmed by histological evaluation of the wound tissue. Therefore, HG containing extracts from H. rhamnoides L. leaves enhanced wound healing effectively, and so may be developed as a cover to promote wound healing. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：586 / 593
页数：8
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