The trifecta of aging in Caenorhabditis elegans

被引:74
|
作者
Wolff, Suzanne [1 ]
Dillin, Andrew [1 ]
机构
[1] Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA
基金
美国国家卫生研究院;
关键词
insulin/IGF-1; signaling; aging; Caenorhabditis elegans; dietary restriction; mitochondria; gluconeogenesis;
D O I
10.1016/j.exger.2006.06.054
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Insulin signaling, mitochondrial respiration, and dietary restriction share conserved roles not only in the regulation of lifespan, but also in the timing and control of diverse functions such as reproduction, stress resistance and metabolism. These autonomous pathways differ in their dependence on known transcription factors and in their temporal requirements, but converge to manipulate the core set of physiological systems necessary for extended lifespan in worms. Recent work suggests that components of these pleiotrophic pathways might be manipulated specifically for their effects on aging without affecting additional downstream functions. Examination of these findings will help us to understand how the molecular mechanisms of distinct pathways can unite in the regulation of longevity. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:894 / 903
页数:10
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