Incorporation of zeolite and silica nanoparticles into electrospun PVA/collagen nanofibrous scaffolds: The influence on the physical, chemical properties and cell behavior

被引：35

作者：

Mehrasa, Mohammad ^{[1
]}

Anarkoli, Abdolrahman Omidinia ^{[2
]}

Rafienia, Mohammad ^{[3
]}

Ghasemi, Nasim ^{[2
,4
]}

Davary, Navid ^{[5
]}

Bonakdar, Shahin ^{[6
]}

Naeimi, Mitra ^{[7
]}

Agheb, Maria ^{[8
]}

Salamat, Mohammad Reza ^{[3
,9
]}

机构：

[1] Univ Isfahan, Fac Adv Sci & Technol, Dept Biotechnol, Esfahan, Iran

[2] Isfahan Univ Technol, Dept Chem Engn, Esfahan, Iran

[3] Isfahan Univ Med Sci, Biosensor Res Ctr, Esfahan 81744176, Iran

[4] ACECR, Royan Inst Biotechnol, Dept Cellular Biotechnol, Cell Sci Res Ctr, Esfahan, Iran

[5] Shahrekord Univ Med Sci, Shahrekord, Iran

[6] Pasteur Inst Iran, Natl Cell Bank Iran, Tehran, Iran

[7] Islamic Azad Univ, Cent Tehran Branch, Dept Biomed Engn, Tehran, Iran

[8] Isfahan Univ Med Sci, Student Res Ctr, Esfahan, Iran

[9] Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2016年 / 65卷 / 09期

基金：

美国国家科学基金会;

关键词：

Polyvinyl alcohol; zeolite; silica; collagen; nanoparticles; tissue engineering; electrospinning; TISSUE; COMPOSITE;

D O I：

10.1080/00914037.2015.1129958

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Cartilage is under extensive investigation in tissue engineering research. Herein, we evaluated scaffolds prepared by composites of polyvinyl alcohol (PVA) and collagen incorporated with zeolite and silica nanoparticles (nZe and nSi). The scaffolds were prepared by the electrospinning method. The mean diameters of nanofibers were 0.61 +/- 0.34 mu m for PVA/collagen versuss 0.62 +/- 0.22 mu m and 0.66 +/- 0.25 mu m for the PVA/collagen/nZe and the PVA/collagen/nSi scaffolds, respectively. DAPI staining results revealed that cell proliferations on the PVA/collagen/nZe and PVA/collagen/nSi were strikingly higher than on the pure PVA/collagen. The results encouraged further investigation of PVA/collagen/nSi scaffolds as biomimetic platform for chondrocyte cells in tissue engineering.

引用

页码：457 / 465

页数：9

共 12 条

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