Control of a Class of Large-Scale Boolean Networks for Biological Systems Using Constant Inputs

被引：0

作者：

Yang, Jung-Min ^{[1
]}

Cho, Kwang-Hyun ^{[2
]}

机构：

[1] Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

来源：

IFAC PAPERSONLINE | 2016年 / 49卷 / 26期

基金：

新加坡国家研究基金会;

关键词：

Boolean networks; stabilization; semi-tensor product (STP); constant control; systems biology; biological networks; CONTROLLABILITY; OBSERVABILITY; CANCER;

D O I：

10.1016/j.ifacol.2016.12.143

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Boolean networks can describe dynamics of genetic and cellular networks in a simple and abstract framework. this paper presents a constant control scheme for stabilization of large-scale Boolean networks. A number of state nodes are selected as constant control inputs So that the Boolean network can reach desirable attractors or cycles. Strongly connected components of the Boolean network are considered to reduce the computational cost. A simulation study on the problem of determining combinatorial targeted drugs for desired cellular phenotype is provided. (C) 2016 IFAC (International Federation Of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

引用

页码：300 / 305

页数：6

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