Transposable element derived DNaseI-hypersensitive sites in the human genome

被引：23
|
作者：
Marino-Ramirez, Leonardo [1 ]
Jordan, I. King [1 ]
机构：
[1] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA
来源：
BIOLOGY DIRECT | 2006年 / 1卷 / 1期
关键词：
D O I：
10.1186/1745-6150-1-20
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: Transposable elements (TEs) are abundant genomic sequences that have been found to contribute to genome evolution in unexpected ways. Here, we characterize the evolutionary and functional characteristics of TE-derived human genome regulatory sequences uncovered by the high throughput mapping of DNasel-hypersensitive (HS) sites. Conclusion: The results reported here support the notion that TEs provide a specific genome-wide mechanism for generating functionally relevant gene regulatory divergence between evolutionary lineages.
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页数：14
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