Transposable element derived DNaseI-hypersensitive sites in the human genome

被引：23

作者：

Marino-Ramirez, Leonardo ^{[1
]}

Jordan, I. King ^{[1
]}

机构：

[1] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

来源：

BIOLOGY DIRECT | 2006年 / 1卷 / 1期

关键词：

D O I：

10.1186/1745-6150-1-20

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Transposable elements (TEs) are abundant genomic sequences that have been found to contribute to genome evolution in unexpected ways. Here, we characterize the evolutionary and functional characteristics of TE-derived human genome regulatory sequences uncovered by the high throughput mapping of DNasel-hypersensitive (HS) sites. Conclusion: The results reported here support the notion that TEs provide a specific genome-wide mechanism for generating functionally relevant gene regulatory divergence between evolutionary lineages.

引用

页数：14

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