Catalytic, asymmetric Baylis-Hillman reaction of imines with methyl vinyl ketone and methyl acrylate

被引：0
|
作者：
Shi, M [1 ]
Xu, YM [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 23期
关键词：
D O I：
10.1002/1521-3773(20021202)41:23<4507::AID-ANIE4507>3.0.CO;2-I
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The chiral Lewis base catalyst TQO, a cinchona alkaloid derivative, facilitates the Baylis-Hillman reaction of various N-arylidene-4-methylbenzenesulfonamides with methyl vinyl ketone (MVK) or methyl acrylate to give the Baylis - Hillman adducts 1 in good yields with high enantioselectivity (90-99% ee).
引用
收藏
页码：4507 / +
页数：5
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