Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity

被引：0

作者：

Liu, Ke ^{[1
,2
,3
,4
,5
,6
,7
]}

Lei, Run ^{[1
,2
,3
,4
,5
,6
,7
]}

Li, Qiong ^{[8
]}

Wang, Xin-Xin ^{[8
]}

Wu, Qian ^{[9
]}

An, Peng ^{[9
]}

Zhang, Jianchao ^{[4
]}

Zhu, Minyan ^{[5
,6
,7
]}

Xu, Zhiheng ^{[10
]}

Hong, Yang ^{[11
]}

Wang, Fudi ^{[9
]}

Shen, Ying ^{[8
]}

Li, Hongchang ^{[4
]}

Li, Huashun ^{[5
,6
,7
]}

机构：

[1] Sichuan Univ, West China Dev & Stem Cell Inst, West China Hosp 2, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Ctr Canc, Chengdu 610041, Sichuan, Peoples R China

[3] Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R China

[4] Chinese Acad Sci, Shenzhen Key Lab Mol Biol Neural Dev, Lab Dev & Regenerat Biol, Inst Biomed & Biotechnol,Shenzhen Inst Adv Techno, Shenzhen 518055, Guangdong, Peoples R China

[5] Tongji Univ, Sch Med, SARITEX Ctr Stem Cell Engn Translat Med, Shanghai East Hosp, Shanghai 200123, Peoples R China

[6] Adv Inst Translat Med, Shanghai 200123, Peoples R China

[7] ATCG Corp, BioBay, Suzhou Ind Pk, Suzhou 215123, Jiangsu, Peoples R China

[8] Zhejiang Univ, Sch Med, Key Lab Med Neurobiol,Minist Hlth China, Dept Neurobiol,Key Lab Neurobiol, Hangzhou 310058, Zhejiang, Peoples R China

[9] Zhejiang Univ, Sch Publ Hlth, Dept Nutr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

[10] Chinese Acad Sci, State Key Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing 100101, Peoples R China

[11] Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Pittsburgh, PA 15261 USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

美国国家科学基金会; 中国博士后科学基金;

关键词：

GENE-EXPRESSION; IRON; CLATHRIN; DOMAIN; GLUR2; TRANSMISSION; SUBUNIT; PHOSPHORYLATION; METABOLISM; MECHANISMS;

D O I：

10.1038/srep21019

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis. However, little is known about its additional function other than iron transport in the development of central nervous system (CNS). Here we demonstrate that TFR functions as a regulator to control AMPA receptor trafficking efficiency and synaptic plasticity. The conditional knockout (KO) of TFR in neural progenitor cells causes mice to develop progressive epileptic seizure, and dramatically reduces basal synaptic transmission and long-term potentiation (LTP). We further demonstrate that TFR KO remarkably reduces the binding efficiency of GluR2 to AP2 and subsequently decreases AMPA receptor endocytosis and recycling. Thus, our study reveals that TFR functions as a novel regulator to control AMPA trafficking efficiency and synaptic plasticity.

引用

页数：14

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