SYNTHESIS OF PYRROL[2,3-d]PYRIMIDINE ANALOGUES: "PYRIDINE RING" ANALOGUES OF PEMETREXED

被引：0

作者：

Xu, Yun ^{[1
]}

Yu, Mingfeng ^{[1
]}

Long, Yan ^{[1
]}

Wu, Han ^{[1
]}

Mao, Zhenmin ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

来源：

HETEROCYCLES | 2009年 / 78卷 / 09期

关键词：

Pemetrexed; Pyridine Ring; Synthesis; Michael Addition; Net Reaction; THYMIDYLATE SYNTHASE INHIBITORS; ANTICANCER AGENTS; LY231514; MTA; ANTIFOLATE; PYRIDO<2,3-D>PYRIMIDINES; METHOTREXATE; TNP-351; ACID;

D O I：

10.3978/COM-09-11725

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two analogues of pemetrexed with its phenyl ring replaced with pyridine ring as novel anticancer agents were synthesized. Preliminary in vitro evaluation indicated that replacement of the phenyl moiety of pemetrexed by the pyridine ring with the 6-5 bicyclic ring system showed low cytotoxicity, that departs from the findings with antifolates bearing 6-6 bicyclic ring system.

引用

页码：2353 / 2360

页数：8

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