Genome-wide association study of fleece traits in Inner Mongolia Cashmere goats

被引：24
|
作者：
Wang, F. H. [1 ]
Zhang, L. [1 ]
Gong, G. [1 ]
Yan, X. C. [1 ]
Zhang, L. T. [1 ]
Zhang, F. T. [1 ]
Liu, H. F. [1 ]
Lv, Q. [1 ]
Wang, Z. Y. [1 ]
Wang, R. J. [1 ]
Zhang, Y. J. [1 ]
Wang, Z. X. [1 ,2 ]
Liu, Z. H. [1 ,3 ]
He, L. B. [3 ]
Su, R. [1 ]
Zhao, Y. H. [1 ]
Li, J. Q. [1 ]
机构：
[1] Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot 010018, Inner Mongolia, Peoples R China
[2] Key Lab Anim Genet Breeding & Reprod, Hohhot 010018, Inner Mongolia, Peoples R China
[3] Minist Agr & Rural Affairs, Key Lab Mutton Sheep Genet & Breeding, Hohhot 010018, Peoples R China
来源：
ANIMAL GENETICS | 2021年 / 52卷 / 03期
基金：
中国国家自然科学基金;
关键词：
fleece traits; genome‐ wide association study; GoatSNP52K Beadchip; Inner Mongolia Cashmere goats; GENETIC-PARAMETERS; IDENTIFICATION; SKIN;
D O I：
10.1111/age.13053
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Inner Mongolia Cashmere goat is a well-known local cashmere goat breed in China. It is famous for excellent fleece quality and a significant advantage in cashmere yield compared to other cashmere goat breeds. In this study, a genome-wide association study was used to investigate fiber length, fiber diameter, and cashmere yield of 192 Inner Mongolia Cashmere goats using the Illumina GoatSNP52K Beadchip panel. We discovered that four single nucleotide polymorphisms (SNPs) reached genome-wide significance levels. These SNPs were located in some genes, e.g. FGF12, SEMA3D, EVPL, and SOX5, possibly related to fleece traits in Inner Mongolia Cashmere goat. Gene ontology enrichment analysis revealed that these genes were enriched in several biological pathways that were involved in hair follicle development in cashmere goats. In summary, the identified significant SNPs and genes provide useful information to explore genetic mechanisms underlying the variation in fleece traits and genomic selection of Chinese cashmere goat.
引用
收藏
页码：375 / 379
页数：5
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