The role of cracks in the crystal nucleation process of amorphous griseofulvin

被引：17

作者：

Willart, J. F. ^{[1
,2
]}

Dudognon, E. ^{[1
,2
]}

Mahieu, A. ^{[1
,2
]}

Eddleston, M. ^{[3
]}

Jones, W. ^{[3
]}

Descamps, M. ^{[1
,2
]}

机构：

[1] Univ Lille Nord France, F-59000 Lille, France

[2] CNRS, UMR 8207, USTL UMET Unite Mat & Transformat, F-59650 Villeneuve Dascq, France

[3] Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England

来源：

EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS | 2017年 / 226卷 / 05期

关键词：

PHYSICAL STABILITY; MOLECULAR MOBILITY; GLASSY CRYSTAL; CRYSTALLIZATION; STATE; POLYMORPHISM; PHASE; PHARMACEUTICALS; TRANSFORMATION; DYNAMICS;

D O I：

10.1140/epjst/e2016-60358-y

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

In this paper we have investigated the recrystallization properties of amorphous griseofulvin obtained by melt quenching. We have shown that the maximum nucleation rates of crystalline forms 2 and 3 are located around the glass transition temperature. However, it appears that these nucleation rates are strongly increased by the sudden formation of cracks into the amorphous solid during deep quenches below Tg. Suitable thermal treatments have revealed that these cracks strongly promote the development of crystalline nuclei, but do not produce the nuclei themselves. The investigations have been performed by differential scanning calorimetry and by thermal microscopy.

引用

页码：837 / 847

页数：11

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