Iron-Catalyzed Borrowing Hydrogen C-Alkylation of Oxindoles with Alcohols

被引：61

作者：

Dambatta, Mubarak B. ^{[1
]}

Polidano, Kurt ^{[1
]}

Northey, Alexander D. ^{[1
]}

Williams, Jonathan M. J. ^{[2
]}

Morrill, Louis C. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff Catalysis Inst, Main Bldg,Pk Pl, Cardiff CF10 3AT, S Glam, Wales

[2] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

CHEMSUSCHEM | 2019年 / 12卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

alcohols; alkylation; borrowing hydrogen; iron catalysis; oxindoles; ONE-POT SYNTHESIS; N BOND FORMATION; ALPHA-ALKYLATION; ENANTIOSELECTIVE FUNCTIONALIZATION; TRICARBONYL COMPLEXES; ORGANIC-SYNTHESIS; NATURAL-PRODUCTS; RUTHENIUM; AMINES; KETONES;

D O I：

10.1002/cssc.201900799

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general and efficient iron-catalyzed C-alkylation of oxindoles has been developed. This borrowing hydrogen approach employing a (cyclopentadienone)iron carbonyl complex (2 mol %) exhibited a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles underwent selective mono-C3-alkylation in good-to-excellent isolated yields (28 examples, 50-92 % yield, 79 % average yield).

引用

页码：2345 / 2349

页数：5

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